ITGAE and neoplasm: To investigate tumor residency, in accordance with previous literature (13), CD8+ T cells were classified based on their expression of CD69 and CD103 as either double negative (DN, CD69-CD103-, ‘circulating’), single positive (SP, CD69+CD103-, ‘intermediate’), or double positive (DP, CD69+CD103+, ‘tumor-resident’, Supplementary Figure 1A).