Neutralization of IL-10 significantly increased the production of SEB-induced IL-5, IL-13, IFN-γ and IL-17A by nasal polyp cells exposed to poly (IC), which illustrates that TLR3 signaling regulates SEB-induced cytokine production in CRSwNP via IL-10 (75). This evidence concerns the gene SETBP1 and chronic rhinosinusitis with nasal polyps.