Suppression of FOXA2 expression in the lung epithelia is also associated with Th2-mediated disease, goblet cell hyperplasia and mucus production: FOXA2 expression was found to be lower than normal in the airways of mild/moderate asthmatic patients and its expression was negatively correlated with expression of Mucin genes, whereas constitutive expression of Foxa2 in murine lung epithelium reduced mucus metaplasia in an asthma model (12). Here, FOXA2 is linked to asthma.