Sensitization to the allergen then drives differentiation of naïve CD4 T-cells to the Th2 effector subset, which further promote allergic asthma by secretion of cytokines and chemokines, amplifying epithelial cell, eosinophil, mast cell and basophil responses, leading to IgE production, chronic inflammation and airway remodelling (3, 4). This evidence concerns the gene CD4 and allergic asthma.