In addition, multivariate Cox proportional hazard regression analyses further determined HHLA2 expression as an independent predictor of melanoma survival (PFS: HR=0.268, 95%CI: 0.126 to 0.571, p=0.001; OS: HR=0.334, 95%CI: 0.147 to 0.755, p=0.008, Table 4). The gene discussed is HHLA2; the disease is melanoma.