Figure 9A showed that cell cycle, DNA repair, purine and pyrimidine metabolism, and biosynthesis of unsaturated fatty acids were significantly enriched in the high-TMB group, while those related to immune cell migration and immune response, such as NOTCH signaling pathway, integrin binding, laminin binding, endothelial cell chemotaxis, and phosphatidylinositol signals, were enriched in the low-TMBrisk group. In addition, immune scores were significantly lower in the high-TMBrisk group, while stromal scores and tumor purity were higher (Figure 9B). The gene discussed is LAMB2; the disease is neoplasm.