Figure 4D shows that 82 gene transcripts were significantly downregulated, while 76 transcripts were significantly upregulated in sCD83-treated RA patient-derived samples when compared to sCD83-treated healthy donor-derived osteoclasts (Figure 4D). Interestingly, we have identified a broad downregulation of RNAs related to the CXCL protein family, including Cxcl1, Cxcl2, Cxcl3, Cxcl5 and Cxcl6 in RA-derived samples after sCD83 treatment, which was not the case in healthy donor-derived samples (Figure 4D). The gene discussed is CXCL5; the disease is rheumatoid arthritis.