Inhibition of melanoma autophagy through targeting at ATG5, p62/SQSTM1 and BECN1 activates MAPK8/JNK-JUN/c-Jun signaling pathway in melanoma cells which up-regulates CCL5 cytokine in the TME and thus enhance NK function via activation of NK cell activator NKp46. The gene discussed is SQSTM1; the disease is melanoma.