HMGB1 and breast cancer: Compared with normal tissues, 23 genes (AIM2, BAK1, BAK, CASP3, CHMP7, CASP5, CASP6, IL-6, CASP8, CHMP2A, CHMP4A, CHM4B, CHMP4C, CYCS, GPX4, GSDMD, TP63, HMGB1, IL1A, TP53, PYCARD, PLCG1, GSDMB, NLRP2, NLRP7) were detected to be up-regulated, while 6 genes (CHMP3, ELANE, NLRP3, NLRP1) were down-regulated in BC group (Figure 2A).