Compared with the hyperglycemia group, in a hyperglycemia context, the ROS content of MIN6 cells transfected with Gm10451 lentivirus was increased, and their SOD activity was decreased (p < 0.05); accordingly, under the same condition, SOD activity of MIN6 cells transfected with Gm10451 siRNA was increased and their ROS content was decreased (Figures 5B,C). The gene discussed is SOD1; the disease is Hyperglycemia.