GSDMD and cancer: Strong evidence has demonstrated that the pyroptosis process is highly involved in the pathogenesis and progression of cancer by inducing GSDMD-dependent caspase-1 inflammasome pathways and other GSDM-dependent non-inflammasome signaling cascades (Johnson et al., 2018; Pizato et al., 2018; Wang et al., 2019; Yu et al., 2019).