Relative to normal tissues, GSDME expression was higher in most cancer types; however, it was lower in bladder urothelial carcinoma (BLCA), BRCA, COAD, KICH, kidney renal clear cell carcinoma (KIRC), PRAD, thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (Figure 1G). Here, GSDME is linked to bladder transitional cell carcinoma.