Six types of GSDMs paralogous genes, namely GSDMA, GSDMB, GSDMC, GSDMD, and GSDME [also termed deafness, autosomal dominant 53 (DFNA5)], and pejvakin [PJVK; also termed deafness, autosomal recessive 59 9DFNB59)], have been found in humans (Liu et al., 2021). The gene discussed is GSDME; the disease is deafness.