GSDME and neoplasm: Recently, it has been reported that two members of the GSDM family, namely GSDMD and GSDME, stimulate numerous downstream pyroptotic pathways, and the downregulation of these molecules conversely contributed to tumorigenesis and proliferation in the tumor cell microenvironment (Wang et al., 2018a; Gao et al., 2018; De Schutter et al., 2021).