On the other hand, studies have shown that in breast cancer, CCL25 increases the expression of matrix metalloproteinases (MMPs), including MMP-2, MMP-3, MMP-9 and MMP-10, which effectively degrade the extracellular matrix (ECM) and promote the invasion of cancer cells (Johnson-Holiday et al., 2011). The gene discussed is CCL25; the disease is breast carcinoma.