APOE and early-onset autosomal dominant Alzheimer disease: These proteins were matched in pathways including cholesterol metabolism (APOAI, APOB, and APOE), vitamin digestion and absorption (APOAI and APOB), fat digestion and absorption (APOAI and APOB), peroxisome proliferator-activated receptor signaling (APOAI), interleukin-17 signaling (S100A8), complement and coagulation cascades (Anti-Thrombin III), thyroid hormone synthesis (Transthyretin), African trypanosomiasis (APOAI), and Alzheimer's disease (APOE).