PDE10A and epilepsy: Three de novo PDE10A mutations [c.898T>C (p.Phe300Leu), c.1000T>C (p.Phe334Leu), and c.1001T>G (p.F334C)] (9, 51–53) have been associated with childhood-onset chorea (5 to 10 years of age) with normal cognitive development and no epilepsy.