We collected and reviewed 74 articles (17 for GNB1, 46 for GNAO1, 6 for PDE10A, 2 for PDE2A, and 3 for HCPCA) describing motor, epileptic, and developmental phenotype of patients with genetic disorders of GPCRs–cAMP signaling pathway. The gene discussed is GNB1; the disease is hereditary disease.