Genes discovered in this pathway and associated with neurological disorders encode transducer molecules or components of the GPCR machinery (i.e., GNAO1, GNB1, GNAL, GPR88), or proteins controlling the synthesis and hydrolysis of the second messenger cyclic adenosine monophosphate (cAMP) (ADCY5, PDE10A, PDE2A). Here, PDE2A is linked to nervous system disorder.