PMLD is autosomal recessive and associated with mutations in connexin 47 (Cx47), which also known as connexin 46.6, gap junction protein γ2 (GJC2), and gap junction protein α12 (GJA12) (Uhlenberg et al., 2004; Bilir et al., 2013; Abrams et al., 2014; Owczarek-Lipska et al., 2019). The gene discussed is GJC2; the disease is Pelizaeus-Merzbacher-like disease.