TOP2A and pancreatic adenocarcinoma: Except for IGFBP3 which hadn’t been found in HPA, as we predicted, protein expressions of PTGS2 (Figures 10A,B, p < 0.01) and TOP2A (Figures 10C,D, p < 0.001) were higher in pancreatic tumor tissue, which was consistent with their correlation with poor survival of PAAD patients.