GLI1 and cancer: Especially, previous studies found that FA2H (Fatty acid 2-hydroxylase) depletion could lead to decreased chemosensitivity to cisplatin via inhibition of AMPK and activation of mTOR/S6K1/Gli1 pathway in gastric cancer (Yao et al., 2019), and turn different cancer cells resistant to PM02734 (Herrero et al., 2008).