Based on a recent assessment of the parent cohort [40], CSF AD biomarker cut-off levels (630 pg/mL for Αβ42 [47], 66 pg/mL for p-tau and 394 pg/mL for t-tau) were established to allow for classification of the included subjects according to the A/T/N classification system (Table 2). Here, PNRC1 is linked to Alzheimer disease.