Last, we were unable to test a potential influence of the body mass index (BMI), or cardiovascular risk factors, such as hypercholesterolemia, on plasma apoE levels and cannot rule out an effect of these although our previous findings in healthy APOE ε3/ε4 subjects suggested that there are no differences in plasma apoE levels between individuals with a pathological (> 25) versus normal BMI [101]. This evidence concerns the gene APOE and Hypercholesterolemia.