PREX2 and nonpapillary renal cell carcinoma: The diagnostic performance of the signature (logit (p = ccRCC) = 1.21943 × KMT2D + 1.97072 × PREX2 + 1.30485), measured by AUC, was 0.836 (p < 0.001; 95% CI, 0.765 to 0.893, Fig. 1C).