FGFR1 and cancer: In the form of molecular chaperones, heat shock protein 90 (Hsp90) synergizes with the signaling pathways involved in cancer cell proliferation, growth, and cellular adaptation, and the Hsp90 inhibitor AUY922 (luminespib) significantly promotes the degradation of the KG-1a fusion oncoprotein FOP2-FGFR1 and inhibits the PI3K and IKK signaling pathways in AML cell lines.