Children in the RTS,S group had significantly increased antibody-mediated FcγRIIa-binding and FcγRIII (IIIa and IIIb)-binding activity targeting CSP after vaccination (M3) compared to baseline (M0), or the comparator non-malaria vaccine group, in both the Manhiça and Ilha Josina study sites (p<0.001 for all tests; Fig. 1A, B; Additional file 1: Figs. S1A and S1B). This evidence concerns the gene DNAJC5 and malaria.