Consistently, CD8+ T tumor-infiltrating lymphocytes isolated from MCA205-bearing mice 15 days after intratumoral injection of DOX (when CSC enrichment occurs), but not of CDDP, displayed a significant increase in the fraction of cells expressing the LGALS9 receptor IC Hepatitis A virus cellular receptor 2 (HAVCR2, best known as TIM3) (Fig. 5d). Here, HAVCR2 is linked to neoplasm.