We demonstrated that IFN-I reprograms cancer cells toward a more aggressive, stem-like phenotype by upregulating KDM1B, an epigenetic regulator also known as LSD2, which erases mono- and dimethyls on histone H3 at lysine 4 (H3K4me1 and H3K4me2)18. The gene discussed is KDM1B; the disease is cancer.