LBP can inhibit the increase of Treg populations and the production of interleukin-10 (IL-10) and transforming growth factor-beta 1 (TGF-β1) in the serum, mitigate the exhaustion of T cells, promote the infiltration of CD8+ T cells in tumor tissue, and maintain the cytotoxicity of lymphocytes30. This evidence concerns the gene CD8A and neoplasm.