The expression levels of complement component C9 (CO9), lipopolysaccharide-binding protein (LBP); Sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1); and von Willebrand factor (VWF) in the EVs of patients with CHB, LC, and HCC were higher than those in HCs (P < 0.05). Here, VWF is linked to hepatocellular carcinoma.