First, we performed gene set enrichment analysis and found a strong correlation between the HCC model’s gene expression profile with that of a previously published gene set defining the clinical molecular subtype of HCC characterized by gain-of-function mutations in the CTNNB1 (β-catenin) gene (NES = 1.4, P < 0.005). Here, CTNNB1 is linked to hepatocellular carcinoma.