At 2-weeks post vaccination, a consistent decrease in IFN-γ ELISpot CD8+ T cells responses, Pb9 (from a malaria parasite) and eGFP200-208 was observed (Fig. 1a–d) in 2′3′-cGAMP vaccinated animals compared to non-adjuvant controls animals (two-way ANOVA main effect analysis: *p = 0.0320 and *p = 0.0484, respectively). The gene discussed is CD8A; the disease is malaria.