PCK2 and breast cancer: Interestingly, PCK2 gene expression has a negative impact on distant metastasis-free survival (Log-rank test Chi2 = 11.70, p = 0.0006250; HR = 1.921) on a pooled breast cancer microarray dataset [16] filtered for intrinsic molecular subtypes enriched for epithelial markers (dataset comprising Luminal A and B from the PAM50 molecular clusters, or Clusters 2 and 4 from the 306 geneset described in Hu et al. [17]) (Fig. 5E).