Mechanistic analysis revealed that the excellent anti‐tumor outcome was attributed to the systematic immune activations and ITM mitigation induced by the three actions, including the increased infiltrations of CD8+ CTLs, NK cells, and memory CD3+ T cells; boosted anti‐tumor cytokine secretions (TNF‐α and IFN‐γ); and decreased myeloid‐derived suppressor cells (MDSCs) in tumor. This evidence concerns the gene TNF and neoplasm.