3) HIFU balanced the immunosuppressive TME.[121] It has been reported that the average value of NK cells, CD3 + T cells, CD4 + T cells, and CD4 +/CD8 + T cells in the peripheral blood of patients with advanced pancreatic cancer after HIFU treatment were all increased.[116, 122] After USgHIFU treatment was administered in 100 patients with pancreatic cancer (PaC) and in 30 patients with uterine myoma (UF), the early subclinical systemic inflammatory responses were triggered as serum LDH, leukocyte, C‐reactive protein (CRP), and IL‐6 were increased. The gene discussed is CD4; the disease is familial pancreatic carcinoma.