found that MWA could activate the ICOS pathway to induce acquired immunity in the treatment of breast cancer.[147] It was also found that the proinflammatory cytokines including IL‐1β and IL‐6 were increased in the circulatory system after MWA treatment, suggesting the occurrence of inflammatory responses.[148] Another team used the single‐cell sequencing technology to analyze and compare the peripheral blood mononuclear cells (PBMCs) of six patients with early breast cancers before and after MWA treatment. This evidence concerns the gene ICOS and breast carcinoma.