TME是肿瘤细胞赖以生存的内环境,TME在增强或抑制肿瘤免疫应答中发挥了重要的作用。EGFR突变可以调节肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes, TILs)[26, 38]、调节性T细胞(regulatory T cells, Tregs)[34, 39, 40]、肿瘤相关巨噬细胞(tumor-associated macrophages, TAMs)[41]和髓系来源抑制性细胞(myeloid derived suppressor cell, MDSC)[41]等免疫细胞及趋化因子[40, 42]以重塑TME,在免疫耐受和免疫逃逸过程中发挥重要作用。. This evidence concerns the gene EGFR and neoplasm.