In this present study, bulk transcriptomic analyses first revealed the positive impact of intratumor γδ T cells on the survival of locally advanced bladder tumor patients, similar to previous studies in other types of tumors.27 31 32 Vδ2 rather than Vδ1 T cells may play a significant role in bladder tumor control, since we observed that BTN3A1 expression, crucial ligand for Vδ2 T-cell activation, correlate with improved patients’ survival. Here, BTN3A1 is linked to urinary bladder neoplasm.