By contrast, some types of ALL with specific genetic alterations, such as t(17;19) TCF3-HLF fusion ALL, may harbor a dismal prognosis.5,6 In this study, we reported a pediatric case of TCF3-HLF fusion ALL wherein BL was initially diagnosed according to morphologic or immunophenotypic characteristics. The gene discussed is TCF3; the disease is Burkitt lymphoma.