The understanding that high IGF-1 and Insulin concentrations in fetuses are predispositions to fetal macrosomia might open a new vista of prenatal assessment of fetal IGF-1 and insulin as well as interventions to prevent fetal macrosomia and its associated maternal and fetal morbidities like higher caesarean section rates, operative vaginal deliveries, increased duration of birth, shoulder dystocia and genital lacerations [24, 31, 32]. The gene discussed is INS; the disease is Large for gestational age.