Examples are increased CD146 expression by IL-13 in airway epithelial cells [30], by endothelin-1 in melanocytes [31], by high glucose in renal tubular epithelial cells [32], and by oxidized-low density lipoprotein (ox-LDL) in macrophages [33]; and decreased CD146 expression by cigarette smoke extract (CSE) and IL-18 in pulmonary ECs [34], by miR-329 in HUVECs and human microvascular endothelial cells (HMECs) [35], and by miR-573 in melanoma cells [36]. This evidence concerns the gene EDN1 and melanoma.