In a recent study, the prevalence of overweight and obesity among young pituitary tumour patients (26.7% and 15.8%, respectively) was slightly lower than reported in our cohort, and was found to be similar to the unselected young population in South Italy, except for patients affected by GH- or ACTH-secreting tumours [21]. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.