The area under the receiver operating curves (AUROC) of plasma NGAL, plasma PENK, plasma NT-proBNP, uNT-proBNP/uCr ratio, and plasma PENK + uNT-proBNP/uCr for predicting CRS-1 in ADHF patients. This evidence concerns the gene LCN2 and TWIST1-related craniosynostosis.