For instance, all the insulin predicted genes are indeed significantly enriched for ‘Diabetes Mellitus’, a disease term that is also recorded as insulin-related in the two hormone–disease ‘ground-truth’ sources that we considered [Endocrine Society (https://www.hormone.org) and DisGeNET (Piñero et al., 2020) resources; see Supplementary File D2a]. This evidence concerns the gene INS and diabetes mellitus.