In glioblastoma, flavonoids also target other pathways, including activation of cell surface death receptors (24), such as kaempferol, which enhances TRAIL-mediated apoptosis through the extrinsic and intrinsic apoptotic pathways (25), and quercetin, which sensitizes glioma cells to death receptor-mediated apoptosis by suppressing the inhibitor of the apoptosis protein surviving (25). The gene discussed is TNFSF10; the disease is central nervous system cancer.