Given that CBL can bind to the P85 subunit of PI3K to promote its ubiquitination, thereby negatively regulating the PI3K/AKT pathway,29 which plays a crucial role in proliferation and metastasis of numerous types of cancer, including GC, the modulation of SERPINA5 on the PI3K/AKT/mTOR signalling pathway was thus taken into consideration. The gene discussed is CBL; the disease is cancer.