Because of this filtering effect, patients on HD should use caution when taking certain medications, such as antihypertensive drugs [1]. People with chronic kidney disease (CKD) may experience hypertension caused by various mechanisms, including an increased vascular volume, increased peripheral vascular resistance, increased activity of the renin-angiotensin-aldosterone system, and decreased renal vasodilator prostaglandins [2]. The gene discussed is REN; the disease is chronic kidney disease.