As a result, anti-S1 antibody titers were significantly higher in the fever group 2 weeks after the second vaccination both in Control group (fever: 2,460 /mL vs non-fever: 1,370 BAU/mL p = 0.0096) and in HD group (fever: 1,375 /mL vs non-fever: 1,030 BAU/mL p = 0.0383) (Fig. 4). Here, PSMD1 is linked to Fever.