To better understand the role of lipid signalling in stroke outcome, the authors studiedindividuals carrying a Single Nucleotide Polymorphism (SNP) in PRG-1 (PRG-1R345T),that was described to prevent the LPA uptake.6 Patients carrying the SNP presented a higher NIHSS at 24 h post-stroke. Here, PLPPR4 is linked to stroke disorder.