LPA uptake is regulated by plasticity relatedgene-1 (PRG-1), which is located in the postsynaptic membrane on glutamatergic neurons.ATX/LPA axis dysregulations are associated with neurological disorders such as neuropathicpain, spinal cord injury, stroke, multiple sclerosis and psychiatric disorders.3,4. The gene discussed is PLPPR4; the disease is stroke disorder.