Preference was also given to genes that mapped within CRC GWAS loci (Cadherin 3 (CDH3), Fas apoptotic inhibitory molecule 2 (FAIM2), von Willebrand factor A domain containing 7 (VWA7), Kazal-type serine peptidase inhibitor domain 1 (KAZALD1) and TRIM31 antisense RNA 1 (TRIM31-AS1)). This evidence concerns the gene CDH3 and colorectal carcinoma.