Meanwhile, ALKBH5 can induce AML chemoresistance by activating PI3K, MAPK, NF-kB, and JAK/STAT pathways, while KDM4C modulates the expression of ALKBH5 via promoting chromatin accessibility and recruiting MYC and Pol II to the promotor [111, 140]. This evidence concerns the gene ALKBH5 and acute myeloid leukemia.