Notably, the APOA1 c.76G > T p.(Glu26Ter), the APOC2 c.214A > T p.(Arg72Trp), and the LMF1 c.668T > A p.(Leu223Gln) variants were classified as likely pathogenic, pathogenic, and likely pathogenic according to the ACMG guidelines, respectively, suggesting that these rare variants may be significantly related to hypertriglyceridemia in individuals with MetS. This evidence concerns the gene APOA1 and metabolic syndrome.