Although many genetic loci related to obesity have been reported through genome-wide association studies (GWAS) in large cohorts of European [13] or East Asian populations [14] and in Genetics of Noninsulin dependent Diabetes Mellitus (GENNID) multiethnic family study [15], no studies have reported rare variants in COL6A2 in subjects with obesity. Here, COL6A2 is linked to type 2 diabetes mellitus.