Eight subjects with MetS had 17 missense variants and 3 nonsense variants in APOB. One subject had a missense variant in SLC2A2, 3 subjects had 3 missense variants in ABCG5, 1 subject had a missense variant in ABCG8, 2 subjects had 2 missense variants in GCKR, and 10 subjects with MetS had 11 missense variants and 1 nonsense variant in LPA. The gene discussed is LPA; the disease is metabolic syndrome.