Among the APOB variants we identified in this study, c.6655C > T p.(Arg2219Cys), c.12853A > T p.(Lys4285Ter), c.7397T > A p.(Leu2466Ter), c.5409C > A p.(Tyr1803Ter), c.3122G < T p.(Gly1041Val), and c.4364T > A p.(Phe1455Tyr) variants were classified as pathogenic or likely pathogenic according to the ACMG guidelines, suggesting a significant relationship of these variants with higher fasting blood glucose levels in subjects with MetS. Here, APOB is linked to metabolic syndrome.