Notably, the c.5897A > G p.(Glu1966Gly), c.5690T > C p.(Phe1897Ser), and c.6068A > T p.(Tyr2023Phe) variants in LPA and the c.169G > T p.(Asp57Tyr) variant in GCKR were classified as pathogen or likely pathogen according to the ACMG guidelines, suggesting that these novel variants are likely to be significantly related to hyperglycemia in individuals with MetS. The gene discussed is GCKR; the disease is metabolic syndrome.