The 3 variants (c.1024_1025delTA p.(Ter342fs), c253C > A p.(Leu85Met), and c.230G > T p.(Cys77Phe) in SPARC related to obesity in our study were classified as pathogenic or likely pathogenic according to the ACMG guidelines, suggesting that these variants may be closely related to obesity. Here, SPARC is linked to obesity disorder.