MTHFR and obesity due to melanocortin 4 receptor deficiency: The 8, 17, 3, 8, and 5 subjects with MetS had the 11 variants in 4 genes (COL6A2, FTO, SPARC, and MTHFR) related to obesity, 39 in 6 genes (APOB, SLC2A2, LPA, ABCG5, ABCG8, and GCKR) related to hyperglycemia, 10 in 4 genes (APOA1, APOC2, APOA4, and LMF1) related to hypertriglyceridemia, 18 in 4 genes (ABCA1, CETP, SCARB1, and LDLR) related to low HDL-cholesterolemia, and 6 in 1 gene (ADD1) related to hypertension, respectively.