Given the altered expression of a significant number of peroxisomal associated genes identified in this and other studies [25, 59], and the demonstration that altered cholesterol metabolism can affect the anti-tumour response of CD8( +) T cells [87], the data presented here further links dysregulation of peroxisome function with effects on T cell infiltration and activity in NSCLC. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.