Therapy of cells expressing NTRK1 fusions with inhibitors of TRKA kinase activity can restrain autophosphorylation of TRKA and cell growth [32]. The imbalance between VWF secretion and ADAMTS-13 may play an important role in the hypercoagulability form in advanced NSCLC. The gene discussed is ADAMTS13; the disease is non-small cell lung carcinoma.