The results suggested that after adjusting gender, age, SBP, BMI, hypertension, diabetes, history of CVD, UPCR, eGFR, ALB, urinary occult blood, use of calcium channel blocker, use of RAAS inhibitor, and use of diuretics, Hb was still negatively associated with renal prognosis (HR = 0.837, 95% confidence interval (CI):0.757 to 0.926) and the annual eGFR decline(β = -0.408, 95%CI:-0.789 to -0.027) (Table 7). The gene discussed is GSTM1; the disease is diabetes mellitus.