For example, the m6A modification of circNSUN2 increases its export to the cytoplasm and circNSUN2 enhances the stability of HMGA2 mRNA to promote colorectal carcinoma metastasis progression, forming a circNSUN2/IGF2BP2/HMGA2 RNA-protein ternary complex [24]. This evidence concerns the gene IGF2BP2 and colorectal carcinoma.