Blocking the IL-17–IκBζ axis effectively suppresses the pathology of psoriasis by downregulating the production of inflammatory mediators in the skin.63 On the other hand, IL-17–IκBζ signaling in IECs does not appear to induce the production of pro-inflammatory molecules, because the expression of inflammatory mediators was not downregulated in our transcriptome analysis of the intestine of Nfkbizfl/flVil1-Cre mice. The gene discussed is NFKBIZ; the disease is psoriasis.