CDA-overexpressing cells in the naïve cell population showed enriched expression of cancer stem cell-related genes such as S100A10 (S100 calcium-binding protein A10)23, LGALS1 (galectin-1)24, and SH3BGRL3 (SH3 domain-binding glutamate-rich protein-like 3)25 (Supplementary Table 6). The gene discussed is SH3BGRL3; the disease is cancer.