Since TGFβ plays a crucial role in immune evasion, angiogenesis, and metastatic niche establishment2,6, crizotinib can suppress tumor metastasis by targeting the tumor microenvironment (i.e., noncell autonomous mechanism), suggesting that crizotinib exerts multilayered, multitargeted antimetastatic properties. This evidence concerns the gene TGFB1 and neoplasm.