Crizotinib also inhibited TGFβ-induced Smad3 phosphorylation in EML4-ALK-positive (H2228 and SNU2535) and EML4-ALK-negative (H1975, Calu-3, and PC-9) NSCLC cells (Supplementary Fig. 7). This evidence concerns the gene ALK and non-small cell lung carcinoma.