Among them, CSF1/CSF1R, VEGFs, and IL13 are essential for the differentiation and survival of macrophages [40], suggesting that the retention of CDK5RAP3 can weaken the survival and cancer-promoting function of M2-like macrophages, and even make newly infiltrated macrophages revert to the anti-tumour phenotype. Here, CDK5RAP3 is linked to cancer.